ABSTRACT

Background: Fructosamine-3-kinase (FN3K) enzyme appears to protect proteins from non-enzymatic glycation. Objectives: The current study aimed to establish the activity of FN3K in serum and erythrocyte lysate. Methods: The activity of FN3K were estimated in (30) healthy individuals and compared to values in (35) non-diabetic myocardial infarction patients. Results: The results showed that there was a significant increase in the activity of enzymes in the lysate of erythrocytes, compared with the activity of enzymes in serum for both the control groups and the patients group. The results also showed a significant increase in the activity of the FN3K enzyme in the serum of patients compared to the control group. The activity of enzymes is not affected by gender for both groups. A group of biochemical variables related to myocardial infarction were measured. The result showed a negative significant relationship between the activity of the enzyme and the level of total antioxidant capacity a positive significance in glycated hemoglobin in the control group, and patients positive significance between the activity of the enzyme and the level of Zn. Conclusion: The activity of FN3K enzyme is affected by age, uncontrolled blood glucose levels, and oxidative stress in healthy patients.