Joshua Allan Joseph1, Uma Radhakrishnan2, Sridhar Mutyala3, Krishnagouda Shankargouda Goudar3, Usha Parackal Thachappully Ayyappan1, Amit Agarwal3
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala, India
2Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala, India.
3Department of Pharmacology and Toxicology, R and D Center, Natural Remedies, Bengaluru, Karnataka, India.
DOI: 10.4103/0976-9668.149119


Background: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee ) in the rodent model. Materials and Methods: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl 4 ) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl 4 , hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated.
Results: Phytocee administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl 4 treated group. Conclusion: The findings suggest that Phytocee markedly reversed the effects of CCl 4 induced oxidative stress and can be used as an antioxidant feed supplement.

Keywords: Antioxidant, carbon tetrachloride, malondialdehyde, oxidative stress, Phytocee.

Please follow and like us:
News Reporter