Fauzul Mobeen1, Md. Zubbair Malik2, Md. Jahoor Alam3, G Reenaroy Devi3, Ravins3, RK Brojen Singh3, Shahnwaz ali2, Md. Badruzzaman2
1School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
2Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, India.
3Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi – 110025, India.
We extended the model of cAMP-PKA pathway in yeast budding by incorporating HOG pathway interaction so that we can able to study signal transduction among the cells. We did large scale simulation of the model by using stochastic simulation algorithm to study the temporal dynamics of each protein involved in the network. Our simulation results indicate the oscillatory behaviours of various proteins involved in the model as is found in experiments. We systematically calculated time period of oscillation, influence of different stress conditions and systems sizes. The dynamics of the proteins are found to be noise induced stochastic process. Read more…