Rajnikant Namdeo1, Prasoon Thakur2, Raghvendra Sachan1, Aneesh Karatti1, Avtar singh1, Megha Wariar3, Meenu Sharma1, Jiwanjot Singh1, Mridhu Goyal1, Shitanshu Kusmakar1
1IBI Biosolutions, SCO 7, Level II, Swastik Vihar, MDC-5, Panchkula, 134109, India.
2IBI Biosolutions, SCO 7, Level II, Swastik Vihar, MDC-5, Panchkula, 134109; Department of computer science, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India.
3Department of computer science, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India.
ABSTRACT
Protein folding into three dimensional structure is much influenced by the weak interactions such as hydrogen bond, hydrophobic, π-π (aromatic-aromatic), Cation-π and Sulphur-aromatic so it plays critical role in establish the three dimensional structure of protein and very important for the protein stability. Therefore it is important to identify the local interactions in the protein three dimensional structures. Hence, Herein, we developed a user friendly, PIPE (protein interaction and properties explorer), a web server for the identification of the local interactions within the protein structure. PIPE Server provides user-friendly, interactive interfaces for the submission of files and visualization of results. PIPE server is developed using HTML, CSS and JavaScript. PIPE programs are coded in Perl-language. Interactive visualization of various local interactions on query protein tertiary structure is implemented using Jmol PIPE server will be a useful resource for the structural bioinformatics community to perform analysis on protein structures based on local protein interaction and to store result at the same platform. Besides this, the program to calculate center of mass of protein also has been implemented. PIPE server is available on the URL http://pipe.ibibiosolutions.com/Home.html. Read more…
