Tazeem1, Mohammad Arshad1, AR Bhat2, Fareeda Athar1
1 Centre for interdisciplinary research in basic sciences, Jamia Millia Islamia, New Delhi-110025, India
2 School of Biotechnology, Yeungnum University, Gyeongsan 712-749, Korea


The innovative research for antibiotics has improved mankind’s health status by confining life threatening infections. However, the emergence and spread of bacterial resistance represent a severe global problem. Heterocyclic especially azoles are widely exposed to therapeutic world, keeping in mind the therapeutic effect of heterocyclic compounds a series of heterocyclic compounds were synthesized and aimed to explore their effect on in vitro growth of microorganisms causing microbial infection. The chemical structures of the compound were elucidated by elemental analysis, FTIR, 1H and 13C NMR and ESI-MS spectral data. In vitro anti-microbial activity was performed against Staphylococcus aureus, Streptococcus pyogenes, Salmonella typhimurium, and Escherichia coli. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibit area/mg of the compounds and the standard “amoxicillin”. The selected compounds were tested for cytotoxic results using MTT assay H9c2 cardiac myoblasts cell line and the results showed that all the compounds offered remarkable >80% viability to a concentration of 200 mg/mL. Read more…

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