D SundarIndian Institute of Technology (IIT) Delhi, New Delhi, India. ABSTRACT A technology for specifically targeting genes of humans has been the ‘Holy Grail’ in genetic medicine. The modular structure of zinc finger domain and modular recognition by zinc finger proteins make…
R SankararamakrishnanDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, U. P., India. ABSTRACT Apoptosis is an important physiological process in which unnecessary and malfunctioning of the cells are removed in a controlled and regulated fashion in multicellular organisms. The…
B JayaramDepartment of Chemistry & Kusuma School of Biological Sciences & Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016, India. ABSTRACT Recent advances in genome sequencing projects and the concurrent developments in scientific softwares…
Shandar AhmadNational Institute of Biomedical Innovation, 7-6-8 Asagi-Saito, Ibaraki-City, Osaka, 567-0085, Japan. ABSTRACT All biological functions can ultimately be described in terms of interactions between proteins, nucleic acids and other smaller molecules. Molecular interactions provide for the enormous complexity of events in…
Tapash Chandra Ghosh, Sandip Chakraborty, Bratati KahaliBioinformatics Centre, Bose Institute, P 1/12, C.I.T. Scheme VII M, Kolkata 700 054, India. ABSTRACT Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level as illustrated…
N SrinivasanMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India. ABSTRACT Protein phosphorylation is a generic way to regulate signal transduction pathways in all kingdoms of life. In many organisms, it is achieved by the large family of Ser/Thr/Tyr protein kinases which…
C Gopi MohanAmrita Centre for Nanosciences and Molecular Medicine (ACNMM), Amrita Institute of Medical Sciences, Ponekkara, Kochi- 682 041, Kerala State, India. ABSTRACT The process of going from a known structure of a pharmaceutical target to an active compound may seem both…
Shradha Khatar, Debasisa MohantyBioinformatics Center, National Institute of Immunology, New Delhi, India. ABSTRACT Post Translational Modification (PTM) typically involve covalent attachment of chemical groups to amino acids of a protein and they play a central role in intracellular signaling in both eukaryotic…
HA NagarajaramLaboratory of Computational Biology, Centre for DNA Fingerprinting & Diagnostics (CDFD), Gruhakalpa, Nampally, Hyderabad 500 00, Andhra Pradesh, India. ABSTRACT Phenotypic effects (“disease” and “neutral”) of a large number of missence mutations caused by nsSNPs as well as rare mutations have…
Sushmitha Vijaya Kumar, V Siva Karthik, Pa Ragul, R Aarthi, Vaibhav Bhatt, Prakash Koringa, Trupthi N PatelAnand Agricultural University, Anand, Gujrat, India. ABSTRACT Soil biota, the rhizosphere swarms with life in the form of microbes. India is one of the major paddy…
