Molecular simulation to biochemical network perturbation in infectious disease

Molecular simulation to biochemical network perturbation in infectious disease

Shailza SinghNational Centre for Cell Science, NCCS Complex, Pune University Campus, Pune 411007, India. ABSTRACT Computational systems biology aims to develop a class of integrated mathematical, computational and experimental techniques with the goal of linking the knowledge of different molecular parts of…

Getting a handhold on designing proteins for human therapeutics

Getting a handhold on designing proteins for human therapeutics

D SundarIndian Institute of Technology (IIT) Delhi, New Delhi, India. ABSTRACT A technology for specifically targeting genes of humans has been the ‘Holy Grail’ in genetic medicine. The modular structure of zinc finger domain and modular recognition by zinc finger proteins make…

Plasticity of hydrophobic grooves in anti-apoptotic Bcl-2 proteins

Plasticity of hydrophobic grooves in anti-apoptotic Bcl-2 proteins

R SankararamakrishnanDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, U. P., India. ABSTRACT Apoptosis is an important physiological process in which unnecessary and malfunctioning of the cells are removed in a controlled and regulated fashion in multicellular organisms. The…

The emerging assembly line of genomes to hit molecules In silico

The emerging assembly line of genomes to hit molecules In silico

B JayaramDepartment of Chemistry & Kusuma School of Biological Sciences & Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016, India. ABSTRACT Recent advances in genome sequencing projects and the concurrent developments in scientific softwares…

Predicting bio-molecular interactions in proteins and nucleic acids

Predicting bio-molecular interactions in proteins and nucleic acids

Shandar AhmadNational Institute of Biomedical Innovation, 7-6-8 Asagi-Saito, Ibaraki-City, Osaka, 567-0085, Japan. ABSTRACT All biological functions can ultimately be described in terms of interactions between proteins, nucleic acids and other smaller molecules. Molecular interactions provide for the enormous complexity of events in…

Exploring the protein complex forming ability in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks

Exploring the protein complex forming ability in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks

Tapash Chandra Ghosh, Sandip Chakraborty, Bratati KahaliBioinformatics Centre, Bose Institute, P 1/12, C.I.T. Scheme VII M, Kolkata 700 054, India. ABSTRACT Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level as illustrated…

Multi-domain protein kinases: Evolution of domain architectures, classification, hybrid protein kinases

Multi-domain protein kinases: Evolution of domain architectures, classification, hybrid protein kinases

N SrinivasanMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India. ABSTRACT Protein phosphorylation is a generic way to regulate signal transduction pathways in all kingdoms of life. In many organisms, it is achieved by the large family of Ser/Thr/Tyr protein kinases which…

Structure-based drug design: Philosophy, strategy and some case studies

Structure-based drug design: Philosophy, strategy and some case studies

C Gopi MohanAmrita Centre for Nanosciences and Molecular Medicine (ACNMM), Amrita Institute of Medical Sciences, Ponekkara, Kochi- 682 041, Kerala State, India. ABSTRACT The process of going from a known structure of a pharmaceutical target to an active compound may seem both…

In silico analysis of enzymes associated with novel post-translational modifications of proteins and peptides

In silico analysis of enzymes associated with novel post-translational modifications of proteins and peptides

Shradha Khatar, Debasisa MohantyBioinformatics Center, National Institute of Immunology, New Delhi, India. ABSTRACT Post Translational Modification (PTM) typically involve covalent attachment of chemical groups to amino acids of a protein and they play a central role in intracellular signaling in both eukaryotic…

Prediction of the effects of missence mutations in human proteins

Prediction of the effects of missence mutations in human proteins

HA NagarajaramLaboratory of Computational Biology, Centre for DNA Fingerprinting & Diagnostics (CDFD), Gruhakalpa, Nampally, Hyderabad 500 00, Andhra Pradesh, India. ABSTRACT Phenotypic effects (“disease” and “neutral”) of a large number of missence mutations caused by nsSNPs as well as rare mutations have…