Accessible surface area in the denatured proteins is the key factor for the perfect urea-methylamine compensation at 2:1 molar ratio under physiological conditions

Accessible surface area in the denatured proteins is the key factor for the perfect urea-methylamine compensation at 2:1 molar ratio under physiological conditions

May 26, 2012

Safikur Rahman, Faizan AhmadCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India. ABSTRACT The potent denaturant, urea accumulates in large concentration in specific cells of various organisms. Urea disrupts protein structures, alters enzymes kinetic properties, interferes with…

Role of salt in urea-methylamine compensation on protein stability and function

Role of salt in urea-methylamine compensation on protein stability and function

May 26, 2012

Md. Tabish Rehman, Safikur Rahman, Faizan AhmadCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India 110 025, India. ABSTRACT In vivo studies show that urea accumulates in large concentration in specific cells of various organisms. In vitro experiments…

Analysis of structural changes on functional domains of WRN gene responsible for werner syndrome

Analysis of structural changes on functional domains of WRN gene responsible for werner syndrome

May 26, 2012

Babita SinghThe Bioinformatica Solutions, Lucknow, U. P., India. ABSTRACT Werner syndrome is a premature aging disorder that may serve as a model of normal human aging. This defect is on a gene that codes DNA helicase and it is located on the…

ECG compression-a novel approach

ECG compression-a novel approach

May 26, 2012

Deepa Mathur1, Ranjan Maheshwari21 Department of Instrumentation Engineering, Government Polytechnic College, Kota-324007, Rajasthan, India2 Department of Electronics Engineering, University College of Engineering, Kota-324010, Rajasthan, India ABSTRACT Electrocardiogram (ECG) is a recording of the electrical activity of the heart over time produced by an electrocardiograph and…

Overcoming resistance to imatinib in chronic myeloid leukemia

Overcoming resistance to imatinib in chronic myeloid leukemia

May 26, 2012

Aditi Shrivastav, Ankita Parihar, Himani Gupta, Neetu Singh, Sudha SrivastavaDepartment of Biotechnology, JIIT University Noida. ABSTRACT Leukemia is an ever increasing worldwide problem causing death every ten minutes. Chronic myeloid leukemia (CML) represents about 14% of all occurrences of leukemias. Imatinib is…

Relevance of ectopic bone formation to the structure of TGF- β superfamily in stress condition; A molecular mechanic vs. clinical study

Relevance of ectopic bone formation to the structure of TGF- β superfamily in stress condition; A molecular mechanic vs. clinical study

May 26, 2012

Babak Khalili HadadDepartment of Biological Sciences, Islamic Azad University, Roudehen Branch, Roudehen, Iran. ABSTRACT Formation of bone outside the skeletal system, which can occur in all kinds of soft tissues, is called Ectopic or Heterotopic Ossification (HO). It is the abnormal formation…

Insilico computation of the effects of antioxidants as potential drug candidates in inhibiting the tweak-FN14 pathway in humans leading to the radiation pathologies

Insilico computation of the effects of antioxidants as potential drug candidates in inhibiting the tweak-FN14 pathway in humans leading to the radiation pathologies

May 26, 2012

Akanksha GuptaDepartment of Biotechnology, IMS Engineering College, Ghaziabad, India.

DNA polymorphism: A biologically relevant phenomenon

DNA polymorphism: A biologically relevant phenomenon

May 26, 2012

Shrikant KukretiDepartment of Chemistry University of Delhi, Delhi 110 007, India. ABSTRACT Nucleic acids (DNA/RNA) are the functional forms of polynucleotides. For years after description of the right-handed DNA double helix by Watson and Crick, DNA was viewed as uniform molecule. But…

Fungicidal activity of allyl alcohol by disrupting ergosterol biosynthesis and membrane integrity against Candida albicans

Fungicidal activity of allyl alcohol by disrupting ergosterol biosynthesis and membrane integrity against Candida albicans

May 26, 2012

Snowber Yousuf, Nikhat Manzoor, Luqman A KhanDepartment of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT This work is an attempt to examine antifungal effect of allyl alcohol against both fluconazole susceptible and resistant isolates of Candida albicans. Total sterol content and…

Biomarkers analysis of oxidative stress as indicator of environmental pollution in liver of walking cat fish (Clarias batrachus) from Yamuna River, Delhi

Biomarkers analysis of oxidative stress as indicator of environmental pollution in liver of walking cat fish (Clarias batrachus) from Yamuna River, Delhi

May 26, 2012

Asif Elahi1, Javed Ahmad2, Mohd. Nauman2, Humayra Bashir2, Farah Khan1, Mohd. Irfan Qureshi21Department of Biochemistry, Jamia Hamdard, New Delhi-110062, India.2Department of Biotechnology, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT Fish are largely being used for the assessment of the quality of aquatic…