Effect of Ozone Therapy on Antioxidant Response in Patients with Diabetic Peripheral Neuropathy

Authors

  • Vazquez-Raygoza Alejandra Guadalupe Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico
  • Milla-Villeda Reinaldo Humberto Faculty of Medicine and Nutrition, Faculty of Physical Culture and Sports Sciences Juarez University of the State of Durango. Clinic of Neuropathy and Herniated Disk of Durango Durango, Mexico
  • Almaguer-Blanco Angel Saul Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico
  • Vega-Ramírez Luis Enrique Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico
  • Zambrano-Galvan Graciela Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico
  • Barragán-Ledesma Laura Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico
  • Quintanar-Escorza Martha Angelica Faculty of Medicine and Nutrition, Juarez University of the State of Durango. Durango, Mexico

Keywords:

Diabetes Mellitus, Neuropathy, Ozone Treatment, Oxidative Stress

Abstract

Background: Type 2 diabetes mellitus is a chronic degenerative disease with multiple complications, including peripheral neuropathy. One of the biochemical mechanisms that explain its pathogenesis and development is oxidative stress. This study aimed to evaluate the oxidative status in diabetic patients with peripheral neuropathy before and after treatment with ozone.

Methods: A total of 25 patients with diabetic peripheral neuropathy were recruited in this study. The disease was classified with the modified Neuropathy Michigan Scorë instrument. Ozone was administered in these patients (27ug/ml) in 12 sessions and the binding activity of Nrf2/ARE, oxidative damage and antioxidant capacity was assessed in their plasma. .

Results: The feet and thighs were found to be the most affected sites (92%), with predominating symptoms such as burning, pain, stitches, numbness and cramps. After ozone therapy, a decrease in these symptoms, HbA1c and binding activity of Nrf2/ARE (p<0.05) was observed. However, the antioxidant capacity and oxidative damage were found to be maintained.

Conclusions: Ozone treatment in patients with diabetic peripheral neuropathy decreased the severity of the symptoms.

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Published

2023-01-26

Issue

Vol. 14 No. 1 (2023): JNatScBiolMed, Vol 14, Issue 1, 2023

Section

Original Article