Authors
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Raniah S. Alotibi
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia
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Hanan Alismail
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia
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Winnie Philip
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Research Unit, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia
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Amerh S. Alqahtani
Medical Genetics Department, King Saud Medical City, Riyadh, Saudi Arabia
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Mariam M. Al Eissa
Medical School, AlFaisal University, Riyadh, Saudi Arabia, Public Health Authority, Public Health Lab, Molecular Genetics Laboratory, Riyadh, Saudi Arabia
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Naif M. Alhawiti
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia
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Mohieldin Elsayid
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia
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Haya Aldhirgham
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
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Amal Alshamery
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
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Manal Jafferi
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
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Njoud Alanazi
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
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Marwh G. Aldriwesh
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia
Keywords:
Coronavirus, COVID-19, Liver Injury, Hematological Parameters
Abstract
Coronavirus Disease 19 was identified to cause severe pneumonia and multisystemic complication including gastrointestinal, and central nervous system. Changes in hematological parameters were reported in several studies among patients affected by SARS-CoV-2 in different countries. Significant liver enzymes elevation in alanine aminotransferase (ALT), aspartate aminotransferase (AST) occurred in a good percentage of patients specially more in sever than mild/moderate COVID-19 patients. Our retrospective study aimed to evaluate the hematological parameters with special emphases on hemoglobin (Hb), ALT, AST, and alkaline phosphatase (ALP) levels in 77 Saudi patients, comparing their levels before and after COVID-19 exposure. The main findings revealed a significant drop in hemoglobin level (p=0.015), while showed a significant elevation in both ALT (p=0.001) and AST (p=0.0001), while significant decrease in ALP (p= 0.016). The platelets, PTT, and creatinine values were statistically insignificant with p value above 0.05. These observations on Saudi patients suggested that a routine liver function test should be performed to monitor liver function and prognosis after recovery.
