Prevalence of Frailty of Alzheimer’s Disease Aged 60 or Older: A Systematic Review and Meta-Analysis

Abstract

Objective: Frailty in elderly frailty can lead to a decline in cognitive function, making daily life more challenging for them. The importance of identifying the prevalence of frailty in the population Alzheimer's disease aged 60 and above lies in understanding the trends and distribution of frailty among older adults. This knowledge can drive efforts in the prevention, treatment, and management of frailty.This meta-analysis aims to evaluate the prevalence of frailty in individuals Alzheimer's disease aged 60 years and above.

 Methods: Relevant research articles on the prevalence of frailty in the elderly were systematically retrieved from databases such as Embase (Elsevier), Medline and PreMedline (OvidSP), PsycInfo (EbscoHost), SCOPUS, and the Cochrane Controlled Trials Register, covering the period to December 2022. Meta-analysis was performed using Revman 5.3 software.

Results: A total of 11 articles, involving 35,453 participants, were included in the analysis. The included articles primarily consisted of randomized controlled trials (RCTs) or cross-sectional studies, which include that ≧60 years old: 4 articles ≧65 years old: 6 articles ≧70 years old: 1 article.The overall prevalence of frailty was found to be 9.23% (95% CI: 1.79~2.04). Subgroup analysis revealed that the prevalence of frailty was higher in elderly females (4.6%) compared to males (3.4%). With increasing age, the prevalence of Alzheimer's disease (AD) (2.7%) was higher than vascular frailty (VD) (0.8%). The prevalence of frailty was lower in illiterate individuals (6.6%) compared to literate individuals (7.2%).

Conclusion: The prevalence of frailty is relatively high in individuals aged 60 years and above. Age, gender, education level, and marital status may influence the occurrence of frailty in the elderly.