Antioxidant and Anti-inflammatory Activity Study of Fulvic Acid

Abstract

Background/Objectives: This study attempted to confirm the possibility of fulvic acid as a functional material. Methods/ Statistical analysis: Anti-inflammatory effects due to antioxidant measurement, as well as the cytotoxicity and NO production inhibition in RAW 264.7 cells were measured using fulvic acid. Findings: In this study, it was shown that fulvic acid enhances DPPH radical elimination and SOD activity. No cytotoxicity was identified in RAW 264.7 cells. Also, after inducing inflammation of RAW 264.7 cells by LPS, NO production inhibiting ability related to the inflammatory reaction was measured to confirm excellent NO production inhibiting effect. Improvements/Applications: Based on these results, it is concluded that fulvic acid has low toxicity to cells, is safe, has excellent antioxidant activity, and has excellent inhibition of NO production related to inflammation, so it can be used as a functional material.