Authors
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Abdulmabod omar
Clinical Pathology Department , Al Azhar university, Egypt
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Mohammad AbdElhameed Alwaseef
Department of clinical pathology, Faculty of medicine, Al Azhar university, Cairo, Egypt
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Ahmed M Ewis
Department of chest disease, Faculty of medicine, Al Azhar university, Cairo, Egypt
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Ibrahim H. Youssef
Department of Chest Diseases, Faculty of Medicine, Al-Azhar University,Cairo , Egypt
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Muhammad Abd Elhameed Khedr
6Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
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Ahmed Gamal Salah Elsawy
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
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Salwa Rashad Aly Said
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
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Ali Fawzy Ali Alhangor
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
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Wagenat E Ali
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
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Ahmed Mohamed abdelsamad
Department of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt
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Asmaa A. Attia
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
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Mostafa Mohamad Elsayed
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
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Zeinab Adawy
Department of Chest Diseases, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
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Laila A Ahmed
Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
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Hany Kamal Ahmed Mahrose
Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt
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Mahmoud Mohammed Mohammed Metwally
Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
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Bassam Abdellatif Mahmoud Elsayed
Department of Chest Diseases, Faculty of Medicine, Al Azhar University, Cairo, Egypt
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Hatem Mohamed Newishy
Medical Microbiology and lmmunology Department, Faculty of Medicine, Al- Azhar University, Cairo, Egypt
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Enas Elsebaee Elsaid Radwan
Department of Clinical Pathology, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt
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Ahmed Abdelhameed Abozeed
Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
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Mohammed Abdulgadir Ageel
Anesthesiology and Critical Care, Department of Surgery - Faculty of Medicine, Jazan University, KSA
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Naema R hussein
Department of Clinical Pathology, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt
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Ibrahim Fadl Mahmoud
Department of Anesthesiology, Intensive Care and Pain Medicine, Damietta Faculty of Medicine, Al-Azhar University, Egypt
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Neazy Abdelmokhles Abdelmottaleb
Department of Anesthesiology, Intensive Care and Pain Medicine, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Keywords:
Calcitonin Peptide Precursor, Procalcitonin, C Reactive Protein, Coinfection in Patients, Viral Pneumonia, ICU
Abstract
Background: Bacterial infection and a non-infectious inflammatory response require a refined distinction for clinical reasoning to be effective. [Calcitonin Peptide Precursor - Procalcitonin (PCT)] and C-reactive protein (CRP) have received considerable attention as inflammatory markers; however, the extent of their competitive diagnostic value, especially in the presence or absence of co-infections, remains fully explored. Methods: This retrospective observational study took account of PCT and CRP levels in 100 patients, fifty of whom had co-infections. Data were processed through non-parametric tests, including the Wilcoxon Signed-Rank Test within groups and the Mann-Whitney U Test across groups. Results: The Wilcoxon Signed-Ranks Test confirmed substantial decreases in PCT and CRP levels post-infection (Z = -6.125, p = .000 and Z = -6.154, p = .000, respectively), signifying the scale of their change. The Mann-Whitney U Test also confirmed the relevance of the investigated biomarkers, as within the group of patients with active infection, both PCT and CRP were significantly raised (PCT: U = 22.000, p = .000; CRP: U = .000, p = .000). The strength of the association between the biomarkers was measured using Spearman’s correlation. Conclusion: Group comparisons demonstrated significant reductions in PCT and CRP from initial to follow-up measurements. A comparison between the groups showed that the co-infection group had significantly higher levels of both PCT and CRP. Weak statistically non-significant correlations were observed between PCT and CRP. PCT and CRP levels were significantly higher in co-infected patients, indicating that these markers may be useful in cognitively diagnosing and monitoring infections. Additional studies are necessary to formulate appropriate diagnostic frameworks.