Fluoride Toothpastes and Mouthwashes: A Review of Formulations, Efficacy, and Usage Patterns in Caries Management

Abstract

Background: Dental caries has consequently emerged as one of the most prevalent chronic disorders affecting individuals across all age groups. Topical fluoride, administered via toothpaste and mouthwash, is a crucial component of caries prevention. Understanding the evolving composition, clinical efficacy, safety concerns, and usage trends of fluoride solutions is essential for optimising individual and population-level oral health activities. Objective: This review examined the chemical compositions, mechanisms of action, comparative efficacy, public health implications, and recent advancements in fluoride toothpaste and mouthwashes. It addresses global practices and risk-based recommendations as well. Methods: A comprehensive literature analysis was conducted utilising the PubMed, Scopus, and Web of Science databases for publications published from 2000 to 2024. Keywords included fluoride toothpaste, fluoride mouthrinse, caries prevention, formulation, and fluorosis. Relevant articles pertaining to the review issue, including randomised controlled trials, systematic reviews, public health data, and regulatory guidelines, were analysed. Results: Sodium fluoride, stannous fluoride, and sodium  monofluorophosphate are recognised fluoride compounds. Fluoride concentrations of 1000 to 1500 ppm in toothpaste reduce caries incidence by 24 to 35 percent, while mouthwashes provide an additional 20 to 30 percent efficacy in individuals at risk. The extent of usage is contingent upon age, geographic location, and socioeconomic status. Dental fluorosis in young children can be managed with appropriate safety measures, provided that dosing and supervision are conducted properly. Emerging technologies, including nano-hydroxyapatite, bioactive glass, and pH-sensitive delivery methods, are enhancing the efficacy of fluoride treatments and their acceptability among patients. Conclusion: Fluoride toothpastes and mouthwashes are accessible, convenient, and versatile means of managing caries. It should be utilised personally concerning risk and integrated into community health assistance strategies. Future research need a similar focus on improving delivery systems, minimising adverse effects, and expanding access for marginalised populations.