• Ozdan Akram Ghareeb
  • Community Health Department, Kirkuk Technical Institute, Northern Technical University, Iraq.
  • Email: ozdanakram@ntu.edu.iq.


The expansion of nanotechnology applications in the medical and health fields coincides with the growing concern about its potential toxicity. This study aims to examine the deleterious impact of titanium dioxide nanoparticles (TiO2NPs) on some hepato-renal biomarkers and the potential attenuating efficacy of Rosmarinus officinalis (RO) in rat model. Twenty-eight male laboratory rats were enrolled in this experiment and were distributed into four groups. The  rats in control group (CO) were not given any dose, while those in TiO2NPs group were treated orally with TiO2NPs by gastric intubation. In addition, the rats in TiO2NPs+RO group were provided with both TiO2NPs and R.officinalis extract orally. The rats in RO group were supplemented only with R.officinalis extract. After the animals were autopsied, the sera were obtained and biochemical tests were performed. Dosing experimental animals with TiO2NPs led to a significant increase in serum levels of the studied biomarkers, however the data also indicated that RO effectively reduced the adverse action of TiO2NPs on liver and kidney functions. In conclusion, R.officinalis extract can be considered defensive against potential nanotoxicity and may be adopted to prevent possible hepato-renal impairment caused by exposure to these toxins.


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