ABSTRACT

Aim: We aimed to investigate whether there is indeed an association between circulating adropin concentrations and cognitive ability. Material and Methods: The study encompassed 400 participants. All of them underwent home interviews and gave consent for collection of their blood, which was subsequently stored at -80°C for later laboratory investigations. The aim was to identify cognitive impairment in patients with dementia and delirium, achieved through the utilization of the Mini-Mental State Examination (MMSE). Furthermore, the Assessment of Neuropsychological Test (ANT) was utilized to evaluate an individual's ability to retrieve information from memory and express it verbally. Results: The average scores for MMSE and ANT showed fluctuations across male and female participants in different quintiles. In the lowest quintile, both males and females performed poorly with an average score of 1.37 ± 0.40 for MMSE and 2.87 ± 0.12 for ANT, while in higher quintiles, there was an improvement male participants showed a mean score of 2.46 ± 0.11 on MMSE with an ANT value at 3.30 ± 0.12, whereas female participants had an average MMSE score of 3.35 ± 0.12 with relatively stable ANT values at ​​3.32±0.18. Regarding adiponectin factors, there were three ranges present: low (3.16±0.50), mid (2.36±0.49), and high (3.27±0.49). For leptin values, the mean scores were around 15, whereas triglyceride values remained consistent at approximately in all measurements taken. Similarly, fructosamine values remained. Conclusion: Human astrocytes have notably high levels of Adropin expression, which is inversely correlated with age but positively correlated with energy metabolism and macromolecule synthesis transcriptomic signatures.