ABSTRACT

To determine the effects of spirulina expression on trophoblast cell apoptosis and caspase-3 expression in a preeclamptic wistar rat model. The preeclampsia model was administered to pregnant rats by interleukin-6 induction. Materials and Methods: This research is a Post Test Only Control Group Design. A total of 25 rats with the preeclampsia model were divided into five groups, namely negative control group, positive control group, treatment group with IL-6 administration, and spirulina with 10 mg, 20 mg, and 40 mg/100 g body weight. Research has shown that spirulina reduces trophoblast cell expression through apoptosis in a rat model of preeclampsia. The positive control group showed the highest mean expression of apoptosis (62.38) and caspase-3 (804.33. The lowest average expression of apoptosis was 44.26, with 592.24 expressions of caspase-3 in group P3, Spirulina treatment at a dose of 40mg/day /kgBW Conclusion: Spirulina inhibits trophoblast apoptosis in preeclampsia through caspase-3 signaling.