ABSTRACT

Background and Objective: Increased serum myostatin level might be one of the causes of impaired protein synthesis and protein degradation associated with decreased muscle mass accompanying older age, which is a component of sarcopenia in CKD patients undergoing hemodialysis. There are still a very limited number of studies with varying and contradictory results. This study aims to analyze the relationship between serum myostatin and sarcopenia levels in elderly chronic kidney disease patients undergoing hemodialysis at Dr. Soetomo Hospital Surabaya. Methods: The design of this study is observational analytics using cross-sectional study design. The scope of population is all chronic kidney disease patients aged ≥60 years old who are registered and undergo hemodialysis at Dr. Soetomo Hospital Surabaya. So it gained 40. All data is analyzed with SPSS statistical program version 25.0. Results: The study subjects experienced sarcopenia as much as 55% and severe sarcopenia 22.5%, while those who experienced presarcompenia and normal by 10% and 12.5% respectively. The median value of serum myostatin levels in this study was 23.75 ng/mL, age range with high myostatin status is obtained in the age group 60-69 years (55%). There was a significant correlation between serum myostatin status with sarcopenia (p=0.002) Conclusion: There is a significant correlation between serum myostatin status and sarcopenia severity in elderly undergoing continuous hemodialysis. The higher the serum myostatin status, the higher the degree of sarcopenia.