ABSTRACT

Background: Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understood. The condition is characterized by hypersensitivity to cereal gluten proteins, and the disease lesion is localized in the gut. Still, the diagnosis can be made by detecting highly disease-specific autoantibodies to transglutaminase 2 in the blood. The aim: The study aimed to determine whether interleukin 10, Igg, IgA, progesterone, oestrogen, FSH and AMH hormones affect celiac disease. Methods: This study was performed from 1st Jan 2023 to Sept 2023 and included 89 patients and 93 controls. On days 2–5 of the menstrual cycle, measurements of serum progesterone, FSH, AMH and oestrogen hormone were performed. Laboratory investigations included immunological factors which include the measurement of interleukin 10 levels by ELISA instrument, as well as measurement Igg, IgA, and chemical factors which include progesterone, FSH, AMH, and oestrogen hormones measured by cobas e 411 analyzer. Results: Evaluation celiac patients for T. IgG, G. IgG and G. IgA was made of (96.98, 13.82, 9.73%) respectively, compared with healthy control subjects was made (8.17, 8.31, 20.68) where (p ≤ 0.001), while evaluation celiac patients for IL-10 was made of (375.8pg\ml), compared with healthy control subjects was made (7.45pg\ml) where (p ≤ 0.001), also evaluation celiac patients for AMH, oestrogen, FSH and progesterone was made (3.92ng/ml, 102.64 pg/ml, 5.15 mlU/ml and 11.20 ng/ml) respectively, compared with healthy control subjects was made (3.21ng/ml, 93.69 pg/ml, 5.08 mlU/ml and 10.18 ng/ml). The mean age of celiac patients was 25.35 year, with a mean age of 25.92 year in healthy control subjects. Also, an evaluation of celiac patients for height, weight and BMI was made (161.44 cm, 61.06 Kg, and 23.46 Kg\m2) respectively, compared with healthy control subjects was made (160.39 cm, 61.93 Kg and 23.91 Kg\m2). Conclusions: Celiac disease may effect the T. IgG, G. IgG and G. IgA, also celiac disease affects the IL-10 but does not effect AMH, oestrogen, FSH and progesterone. Recommendation: Investigate the role of other cytokines, like IL-6 or TNF-α, in celiac disease