• Asmaa Ahmed Hatem Sultan
  • Middle Technical University, Technical Medical Institute, Baghdad, Iraq.
  • Email: assma2222@mtu.edu.iq.

ABSTRACT

Objectives: This study aims to compare the nano-solution made from cinnamon extract with the effect of the nano-solution made from turmeric mixed with the nano-solution made from aloe vera in inhibiting the growth of fungi and bacteria. The importance of the study is due to the urgent need to find materials to treat pathogenic bacteria quickly, especially bacteria that are difficult to treat and at low costs. Methodology: The study is scientific, medical, and applied. The nanomaterials were observed when examining the nano solution made from plant extracts. They were tested on bacteria isolated from collecting samples by wound swabs using a sterile swab and then transferred to the laboratory for cultivation on culture media. Bacteria and fungi were isolated and examined. The isolates are Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Enterobacter cloacae, Stenotrophomonas maltophilia, Acinetobacter baumannii, Staphylococcus epidermidis, and Pseudomonas aeruginosa, which infect the skin from patients’ wounds in some hospitals. Results: It was noted that the effect of the solutions manufactured using concentrations of (75, 50, 25, 100)% m of the nano-turmeric extract solution, where the average ranged at a concentration of 100% between 12-23 mm, was less effective than the solutions manufactured from the nano-cinnamon extract, where the average diameters of the inhibitory zones in the bacterial culture reached 23-60 mm. It was also found that the nano-turmeric extract solution mixed with the nano-aloe vera extract solution was more effective than the nano-cinnamon extract solution mixed with the nano-aloe vera extract solution manufactured at concentrations of (1.0, 0.05, 0.07, 0.01)% m. It was also found that the average diameters of the inhibitory zones of the cultured bacteria treated with the mixed nano-solutions at a concentration of (0.07% m) ranged between 30-47 mm. These nano solutions manufactured with plant extracts are more effective than industrially manufactured nano solutions. It was found from treating these manufactured nano solutions with a culture of pathogenic fungi isolated from wounds, including Candida albicans, that the average diameters of the inhibition zones for all solutions ranged between 10-35 mm at a concentration of 100%. As for Trichophyton mentagrophytes, all solutions inhibited the growth of fungi, and no increase was observed due to the treatment. All solutions inhibited growth by 100%, and no fungal growth was observed. The cytotoxicity of the nano solutions was tested, and they were non-toxic. It was possible to prepare fast and effective nano solutions to treat bacteria and fungi quickly and cheaply. Conclusions: Solutions made from nano-turmeric extract mixed with nano-aloe vera extract solution can be used to treat bacterial wound infections as well as fungal infections. Recommendations: The research contributes to the rapid treatment of bacterial infections and reduces costs, the use of medications, and the occurrence of complications among patients, preventing them from staying in hospitals for a long time.

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