ABSTRACT

Background: Pregnancy inherently enhances the body’s propensity for coagulation, while the COVID-19 vaccinations additionally modify immune response systems that affect haemostasis. Observations of pregnancy-associated elevations in FDPs suggest that information regarding FDP fluctuations during the trimester following COVID-19 vaccination is scarce. The objective of the study is to examine the correlation between COVID-19 immunisations administered throughout various pregnancy trimesters and FDP levels in normal pregnancies, while also contrasting these results with those of non-pregnant adult women. Methods: The study had 160 female volunteers categorised into four groups: first, second, and third trimester pregnant women, along with non-pregnant controls, each group containing forty subjects. Participants were classified into two groups according to their COVID-19 immunisation status: vaccinated and unvaccinated. FDP concentrations were evaluated via a commercial immunoturbidimetric technique. The study employed non-parametric statistical techniques, specifically the Kruskal-Wallis and Mann-Whitney U tests, in conjunction with Spearman’s correlation analysis, with a p-value of less than 0.05 denoting statistical significance. Results: FDP levels recorded during pregnancy demonstrated a steady increase, with vaccinated individuals exhibiting higher FDP readings compared to unvaccinated controls (p < 0.001). All readings documented throughout gestation were within the typical physiological parameters. No thrombotic events were observed. A strong statistically significant link was seen between COVID-19 vaccination and elevated FDP values (ρ = 0.714, p < 0.001). Conclusion: Pregnant people vaccinated against COVID-19 exhibit modest yet physiologically adequate elevations in FDP levels, especially during the later stages of gestation. This study underscores the necessity for pregnancy-specific reference ranges to prevent the misdiagnosis of coagulation disorders in expectant mothers