AP Shaheena1, Poornima A Manjrekar2, Vivian D’souza3, Padmanabh Kamath4, MS Rukmini2, Vinod Chandran2, Durgarao Yalla2, Mukund P Srinivasan5
1Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore, MAHE, Karnataka, India.
2Department of Biochemistry, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
3Department of Biochemistry, Kanachur Medical College, Deralakatte, Mangalore, MAHE, Karnataka, India.
4Department of Cardiology, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
5Department of Internal Medicine, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66% (n = 46) were deficient, 20% (n = 14) were insufficient, and 14% (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = −0.17, P = 0.14) and hs-CRP levels (r = −0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = −0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.
Keywords: Coronary artery disease, Gensini score, high-sensitivity C-reactive protein, Vitamin D.