Arun H S. Kumar
Editor in Chief, Journal of Natural Science, Biology and Medicine, University College Dublin, Dublin, Ireland.
DOI: 10.4103/jnsbm.JNSBM_126_18

Inflammation is the hallmark of all pathology, which can either have acute or chronic timeframe. It will be reasonable to state that any acute compromise in anatomy or physiology will progress with some form of inflammation, which may be localized or generalized. Inflammation is hence regarded as a body’s first response self-defense mechanism to prevent further harm and create a localized environment, which may favor the reparative process. It is likely that a self-regulated inflammatory process is integral to body’s reparative and regenerative process. However, inflammation is not always self-regulating, and on several occasions inflammation may persist for a longer duration, switching the balance toward more progressive harm than benefits. It is hence important to understand the biological differences between controlled and uncontrolled inflammation, to not only achieve optimal endogenous repair/regeneration but also to identify selective target/s to bring inflammation under control. For instance, the inflammatory processes at the interface of physiology and pathology will have potential to be developed as anti-inflammatory drugs, while the inflammatory processes at the interface of pathology and repair will have potential to develop novel class of proregeneration drugs or drugs enhancing regenerative therapy. Read more…