Indrianti Asril, Vivian Soetikno, Purwantyastuti Ascobat
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
DOI: 10.4103/jnsbm.JNSBM_31_19


Objective: Tuberculosis (TB) treatment is associated with various adverse drug reactions (ADRs). The aim of this study was to determine the associations between ADRs and the rate of TB treatment dropout among the patients at Cempaka Putih Islamic Hospital in Jakarta, Indonesia. Materials and Methods: A cross-sectional study was conducted based on the medical records of the TB patients treated at Lung Polyclinic of Cempaka Putih Islamic Hospital between January 2016 and December 2017. Results: Of 178 study participants, 80 had a history of ADR while the other 98 did not. There were statistically significant relationships between the rate of TB treatment dropout and the characteristics of patient, including the age (P = 0.022, prevalence ratio [PR] = 0.599, 95% confidence interval [CI] = 0.408–0.870) and ADR type (P = 0.001, PR = 5.333, 95% CI = 1.402–20.285). Furthermore, there were significant relationships between ADRs and comorbid disease (P = 0.000, PR = 1.871, 95% CI = 1.370–2.555). However, ADR treatment status based on the given guidelines does not have a statistically significant relationship with the rate of TB treatment dropout (P = 0.172, PR = 2.028, 95% CI = 0.582–7.071). Conclusion: The results of this study showed that age and ADR type significantly increased the prevalence of the rate of TB treatment dropout among our patient cohorts.

Keywords: Adverse drug reaction, anti-tuberculosis drugs, patient dropouts, tuberculosis.

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