Sriram Kaliamoorthy1, Vijayparthiban Sethuraman2, Sathish Muthukumar Ramalingam1, Sandhya Arunkumar1
1Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chettinad Health City Campus, Kelambakkam, Kancheepuram, Tamil Nadu, India.
2Department of Oral and Maxillofacial Surgery, Chettinad Dental College and Research Institute, Chettinad Health City Campus, Kelambakkam, Kancheepuram, Tamil Nadu, India.
Oral squamous cell carcinoma with prominent clear cell differentiation is a rare occurrence. A 35-year-old female patient presented with a nonhealing ulcer persistent for 1-month involving the left lateral border of the tongue and lingual vestibule. Lobules of malignant squamous epithelial cells with abundant cytoplasm and vesicular nuclei in the connective tissue were observed following histopathology. Neoplastic cells constituting majority of lobules exhibited clear cell changes. Periodic acid-Schiff and mucicarmine stains showed negative reaction. Immunohistochemical study using antibody for cytokeratin, revealed diffuse and intense positivity. The neoplastic cells showed complete negative reaction with antibodies for vimentin, smooth muscle actin and homatropine bromide-45 antigens.
Keywords: Clear cell, oral cancer, squamous cell carcinoma.