Masoud Negahdary1, Zahra Arefian2, Hajar Akbari Dastjerdi2, Marziyeh Ajdary3
1Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Department of Biology, Payame Noor University, Isfahan, Iran.
3Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Isfahan, Iran.
Background and Objective: The safety of Mn 2 O 3 nanoparticles (which are extensively used in industries) on male reproductive system is not known. Hence, we investigated the effects of Mn2O 3 nanoparticles on male reproductive system. Materials and Methods: A total of 40 Wistar adult male rats were randomly assigned to four groups of 10 rats each. Three groups received Mn2O3 solution in concentrations of 100, 200, and 400 ppm orally for 14 days; the control group received equal volume of saline solution. Blood samples and testicles were collected for analysis. Results: Significant reduction in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, spermatogonial cells, primary spermatocyte, spermatid and Leydig cell was observed in the Mn2O3 nanoparticles treated groups compared with controls. Conclusion: Mn2O3 nanoparticles significantly reduce FSH, LH, and testosterone levels resulting in a significant reduction in testicular cytology.
Keywords: Follicle-stimulating hormone, luteinizing hormone, Mn2O3 nanoparticles, testosterone, toxicity.