M Krishnamoorthy, Reena Balakrishnan
Department of Post Graduate Studies and Research in Biosciences, Mangalore University, Mangalagangothiri, India

DOI: 10.4103/0976-9668.127298

ABSTRACT

Introduction :Plants have a long history of use in the treatment of cancer. Plant-derived compounds have played an important role in the development of several clinically useful anticancer agents. In the recent years, more emphasis has been placed on identifying plant-derived compounds that can be used as an effective treatment for life-threatening diseases such as cancer. Cancer is a disease where there is abnormal cell proliferation. The proliferation of the cancer cells are restrained by cdk/cyclin complexes, which control the normal process of cell cycle. Materials and Method : The current study involves the investigation of the anticancer property of the chemical compounds present in the leaves of Azadirachta indica by performing docking studies with the cell cycle control protein using Arguslab. Result : The compounds were docked with the cdk1 protein to identify suitable inhibitors against the protein function. Conclusion : The study were conducted on yeast Cdk protein, because these proteins showed homology with the human Cdks

Keywords: ArgusLab, Azadirachta indica, cancer, cyclin-dependent kinase, docking