Itishri Jena1, Sarthak Ranjan Nayak1, Sudeshna Behera1, Bratati Singh1, Subhashree Ray1, Diptimayee Jena2, Santosh Singh3, Subrat Kumar Sahoo4
1Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
2Department of Biochemistry, MKCG Medical College, Berhampur University, Berhampur, Odisha, India.
3Department of Medicine, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
4Department of Pediatrics Surgery, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
Background: Oxidative stress is characterized by increased production of reactive oxygen species resulting in the generation of lipid peroxides such as malondialdehyde (MDA). The studies have shown that ischemia-modified albumin (IMA), which has widely been studied as a marker of ischemia, also increases as result of oxidative stress. Hence, the current study was done to evaluate the serum MDA, IMA along with serum uric acid, and albumin, which are important metabolic antioxidants. Materials and Methods: Fifty patients with acute ischemic stroke were taken as cases and compared with 50 age- and sex-matched controls. Serum MDA, IMA, uric acid, and albumin were estimated both in cases and controls. Serum MDA was estimated by the method of Satoh and IMA by Bar-Or et al. The results were analyzed statistically. Results: Serum MDA and IMA values were significantly increased in cases (P < 0.0001), whereas serum uric acid and albumin values were significantly decreased (P < 0.05) in comparison to controls. There was also highly significant positive correlation between serum IMA and MDA (r = 0.843,P < 0.0001), whereas there were significant negative correlations between serum IMA and uric acid (r = −0.237,P < 0.05), and albumin (r = −0.326,P < 0.05). Conclusion: Hence, we conclude the oxidative stress plays a major role in the etiopathogenesis of acute ischemic stroke, and the deranged oxidant-antioxidant balance further contributes to its severity.
Keywords: Acute ischemic stroke, ischemia-modified albumin, malondialdehyde, oxidative stress, reactive oxygen species.