M Idreesh Khan1, Kauser Usman2, W Ali3, MZ Idris1
1Department of Community Medicine, CSM Medical University UP, Lucknow, India.
2Department of Medicine, CSM Medical University UP, Lucknow, India.
3Department of Pathology, CSM Medical University UP, Lucknow, India.
The microvascular complications of diabetes may be mediated, at least in part, through oxidative stress and Zn plays a key role in the cellular antioxidative defense. If there is insufficient Zn, oxidative stress may damage the cell irreversibly, producing inflammation.This study to evaluate the effects of zinc sulfate in comparison with placebo on markers of glycemic control, inflammation and lipid levels in type-2 diabetes with microalbuminuria patients. Type-2 diabetes with microalbuminuria patients were divided into two groups. One group (n=27) received a placebo, second group (n=27) received 50 mg zinc as zinc sulphate. Both groups received oral hypoglycaemic agent with ACE inhibitors. Biochemical and 24 urine examination were carried out at the start of the treatment and after 12 weeks of the regimens. This double blind, randomized, placebo-controlled trial was conducted among north Indian patients. In addition to anthropometric measures and blood pressure, fasting plasma glucose, Post-Prandial glucose, lipid profile, high-sensitivity C-reactive protein (hs-CRP) and 24-hrs urine microalbumin levels were determined.There were no significant differences in biochemical status amongst groups at baseline. After 12 weeks, the number of patients was almost equal in all the groups. Irrespective of the order of receiving zinc and placebo, in both groups, significant decrease was documented for total and LDL-cholesterol after receiving zinc without significant change after receiving placebo. In groups, hs-CRP markers of inflammation decreased significantly after receiving zinc. In both groups, the mean body mass index (BMI) remained high, after receiving zinc, decreased significantly. Thus it seems likely that zinc supplementation to diabetic nephropathy patients provide effective antioxidative/anti-inflammatory protection. Read more…