Shradha Khatar, Debasisa Mohanty
Bioinformatics Center, National Institute of Immunology, New Delhi, India.

ABSTRACT

Post Translational Modification (PTM) typically involve covalent attachment of chemical groups to amino acids of a protein and they play a central role in intracellular signaling in both eukaryotic and prokaryotic cells. Because of their role in central signaling pathways they are either stimulated or targeted by pathogens for promoting their survival in the host. Therefore for identification of enzymes involved in novel PTMs and their target proteins/pathways has been an active area of research. In this work, we have carried out computational studies to analyze various enzymes and target proteins involved in two of the newly discovered post translational modifications, namely AMPylation and Eliminylation. Read More …