Priyanka Narad1, Abhishek Sengupta1, Gulshan Wadhwa2
1Amity University, Noida, India.
2Apex Biotechnology Information Center, Department of Biotechnology, Ministry of Science & Technology, New Delhi, India.
Cytogenetic, genetic and functional studies have demonstrated a direct link between deregulated Hoxa9 expression and acute myeloid leukemia (AML).These important proteins have been the subject of intense scientific studies for a long time but their complete evolutionary history is yet to emerge. A simple classification of protein sequence of hoxa9 and similar sequences from other organisms were used to construct phylogenetic trees which could depict the evolutionary relationships between the different species. The main aim was to establish an evolutionary aspect of hoxa9 protein in conjugation with the occurrence of acute myeloid leukemia (AML). The disease of a frequent occurrence in the other species which share an evolutionary relationship with the humans. As a result studying the disease in closely related species will provide us an insight to finding out a putative therapeutic target for the deregulation of the protein. The popular platform MEGA4 was used for the phylogenetic constructions. With the help of our studies we have tried to establish the most closely related species in terms of the sequence among the closely related species of humans and thus studying the expression of the sequence in these species to infer some conclusions about the role of AML in species other than humans to find out a good model organism. In course of our study we discovered that Mus Musculus is in clade -II which is a bit farther in the phylogenetic tree thus we hypothesize this might be due to some biological transfer. Read More …