Irengbam Rocky Mangangcha1, Vikas Singh Rathore2, Indrakant K Singh1, O Bidyarani3
1Deshbandhu College, University of Delhi, Delhi, India.
2Department of Zoology, University of Delhi, Delhi, India.
3Dr. B.R Ambedkar University, Agra (U.P.), India.
Polycystic Ovarian Syndrome (PCOS) is an endocrinopathy in reproductive aged women which manifests hirsutism, menstrual disturbances, acne vulgaris, obesity, male pattern baldness, infertility, anovulation, psychological morbidity and hyperandrogenism. Our aim was to explore the prevalence of insulin resistance in selected north Indian women with PCOS and to decipher their clinical and metabolic characteristics and to find association of genetic polymorphisms with the insulin resistant PCOS. Investigation was carried out on 154 North Indian women with PCOS, which were selected from 200 infertility patients came in the infertility clinic for IVF and 30 non-hirsuit ovulatory women were taken as control. The transvaginal ultra sonography (USG) report of 65.3% of the patients showed the presence of cystic ovary in the population. The statistical analysis using Student t- test established the prevalence of insulin resistance in the present PCOS patients to be 52.8%. Since LH (Luteinizing Hormone) plays vital role in this endocrinopathy, our study found that the serum LH level was tremendously high in PCOS population with insulin resistance. Genetic studies in other ethnic Asian populations have also reported that PCOS is associated with SNPs (Single Nucleotide Polymorphisms). The elevated LH level in PCOS patients is reported to be related to the SNP rs13405728 at position Chr 2p16.3 in Chinese Han women. It was also reported that T/C SNP at codon Cys1008 in the insulin receptor INSR is associated with insulin resistance in PCOS patients in Chinese women. Further we need to study the insight of SNPs in Indian PCOS women with insulin resistance. Read more…