Md. Aasif Dar, Md. Imtaiyaz Hassan, Faizan Ahmad
Centre for Interdisciplinary Research In Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi -110025, India.
Proteomics studies are used to identify, quantify the protein expression in any tissue, organelle and organism. In past decades proteomic studies on several biological fluids from human was studied extensively. Recently, many proteomic studies have been performed for human kidney in order to understand the mechanism of osmoregulation. Here, our aim is to study the total number of proteins, types of proteins and their function in the mammalian kidney. By studying the literature of proteomic techniques based on fractionation and liquid chromatography coupled with two-dimensional gel electrophoresis, there are 1559 proteins identified so far. Among these, 212 different types of protein were identified.On the basis of molecular function they are classified as: cell adhesion molecules (6), cell cycle and proliferation (4), cell death (1), cell motility (12), cell organization (12), cell-cell signalling (1), immune response (6), developmental processes (11), DNA metabolism (2), RNA metabolism (19), protein metabolism (22), other metabolic processes (33),signal transduction (18), stress response (8), transport (18),other processes (7) and biological function unknown proteins (24). The analysis of total number of proteins and their relative expression will be helpful to understand the precise mechanism of osmoregulation. Read more…