University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16, Dwarka, New Delhi, India.
Growing number of gene expression datasets and availability of hundreds of bacterial genomes facilitated the quest for construction of bacterial (TRNs). TRN discovery integrates a preliminary TRN, microarray, gene ontology (GO) & phylogenic similarity to discover TRN. Methodology can extract more information when gene-gene scores are transformed to gene-transcription factors (TF) using preliminary TRN.TRND MMI is found to be facilitated by the use of a Bayesian framework for each method derived from its individual scoring measure and training set of gene/TF regulatory interactions. TRNs constructed are better compatible with microarray data and adds information to multi-dimensional genome annotation of E. coli K12. Read more…