Subhash Mohan Agarwal
Bioinformatics Division, Institute of Cytology and Preventive Oncology (icmr), I-7, sector-39, Noida-201301, India.
Protein tyrosine kinases, which are responsible for development of many cancers, have emerged as a major class of drug targets in recent years. Among them, one of the receptor tyrosine kinase is Epidermal growth factor receptor (EGFR), which is involved in cell proliferation, differentiation, and motility. The domain architecture consists of a large extracellular ligand binding domain, a transmembrane region and a kinase domain. Upon ligand binding the extracellular signal is transmitted through the tyrosine kinase domain and activates the downstream signaling process. Thus identifying the key residues within kinase domain that are responsible for maintaining the catalytic activity is important and essential for developing therapeutics for human cancers that are associated with abnormal regulation of EGFR kinase activity. Read More ..