Simranjit Singh, Venkatapathy Ramesh, Balakrishnan Premalatha, Karthikshree Vishnu Prashad, Koliyan Ramadoss
Department of Oral Pathology and Microbiology, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.
Background: Alterations in serum lipids have long been associated with cancer as lipids play an important role in maintenance of cell integrity. Aims: To evaluate alterations in plasma lipid profile in oral cancer patients, to compare and correlate the serum lipid profile in different grades of carcinoma and to evaluate the correlation of serum lipid profile between the tobacco habituates and non-habituates. Materials and Methods: Among 75 study subjects, 50 individuals were oral carcinoma patients and 25 individuals were healthy controls. The parameters assessed included total cholesterol (TC), high-density lipoprotein-cholesterol (HDLC), low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and triglycerides (TGL). These groups were subdivided into subjects with no habit of tobacco (NHT) and subjects with habit of tobacco (WHT). Stastical Analysis Used: Evaluation of results and statistical analysis was carried out using Student’s t-test and one-way Analysis of Variance. Results: There was a significant decrease in TC, HDLC and TGL in the oral cancer group as compared with the control group. The lipid profile levels between histological grading of the oral cancer and between WHT and NHT had no statistical significance. Conclusions: There was an inverse relationship between serum lipid profile and oral cancer. The lower serum lipid status may be considered a useful indicator for initial changes occurring in the neoplastic cells.
Keywords: Histological grades, lipids, oral cancer, tobacco abuse.