Kunal Mahajan1, Arvind Kandoria1, Rajeev Bhardwaj1, Prakash Chand Negi1, Sanjeev Asotra1, Gunjan Gupta2
1Department of Cardiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
2Department of ENT, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Background: Limited data exist regarding the risk factor and angiographic profile of coronary artery disease (CAD) in Indian women presenting with anginal chest pain. Methods: In this single-center study, we prospectively analyzed data from 674 consecutive female patients who underwent coronary angiography for suspected CAD over a period of 2 years (2015–2017). Results: Patients were divided into three groups according to age as follows: Group 1 (<45 years), Group 2 (45–55 years), and Group 3 (>55 years). Women in Groups 2 and 3 were more likely to be smokers and were more likely to have diabetes, hypertension, and high-density lipoprotein-cholesterol <40 mg/dl. In contrast, younger women (Group 1) were more likely to have a positive family history of a premature CAD, Body mass index >23 Kg/m2, deranged Low density lipoprotein-cholesterol, and serum triglycerides. Obstructive CAD was seen more often in Group 3 patients (67.6%) compared to Group 2 (45%) and Group 1 (40.4%) (P < 0.0001). Normal epicardial coronaries/nonobstructive CAD and endothelial dysfunction were seen more commonly in Group 1 patients in comparison to Group 2 and 3 patients. Conclusion: The present study provides the largest contemporary data from an Indian female cohort undergoing coronary angiography. As the age advances, there occurs an increase in the number of CAD risk factors as well as the angiographic extent of disease.
Keywords: Angina, coronary angiography, women.