Konda Mani Saravanan1, Renganathan Senthil2
1Centre of Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University, Madurai, India
2Department of Bioinformatics, School of Biosciences, The Marudupandiyar Institutions (Affiliated to Bharathidasan University), Thanjavur, Tamil Nadu, India.
Aim: The PreFRP web server extracts sequence and basic information of a protein structure and groups amino acid residues in a protein into three important types such as high, moderate, and weak fluctuating residues. Materials and Methods: The server takes a protein data bank file or an amino acid sequence as input and prints the probability of amino acid residues to fluctuate. The server also provides a link to Jmol, a molecular visualization program to visualize the high, moderate, and weak fluctuating residues in three different colors. Results: Prediction and visualization of fluctuating amino acid residues in proteins may help to understand the complex three-dimensional structure of proteins and may further help in docking and mutation experiments. Availability: The web server is freely accessible through the web page of the author’s institution http://www.mpi.edu.in/prefrp/link.html.
Keywords: Binding site, carbon content, conformation change, fluctuation residues, intrinsic disorder.