Shantibhusan Senapati1, Sujit Suklabaidya2, Hrudananda Mallik1, Sabyasachi Panda3, Datteswar Hota3, Manas R Baisakh4
1Department of Translational Research and Technology Development, Institute of Life Sciences, Tumor Microenvironment and Animal Models Lab, Bhubaneswar, India.
2Department of Translational Research and Technology Development, Institute of Life Sciences, Tumor Microenvironment and Animal Models Lab, Bhubaneswar; Department of Urology, Manipal University, Manipal, Karnataka, India.
3Department of Urology, SCB Medical College, Cuttack, Odisha, India.
4Department of Pathology, Apollo Hospital, Bhubaneswar, Odisha, India.
We report a very rare case of urinary bladder stone in a laboratory rat, which was associated with severe prostatitis and seminal vesiculitis. Importantly, the histopathological analysis revealed the rare variety of keratinizing desquamative squamous metaplasia of bladder, prostate, and seminal vesicle epithelium. Immunohistochemistry for alpha smooth muscle actin protein and aniline blue staining for collagen clearly showed interstitial prostate fibrosis. The detail information about these findings and subsequent discussion are provided here.
Keywords: Bladder stone, fibrosis, infection, metaplasia, prostate, rat.