Debasis Debadatta Behera1, Bratati Singh2, Suresh Kumar Behera3, Subhashree Ray2, Kamal Lochan Das1
1Department of Biochemistry, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India.
2Department of Biochemistry, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
3Department of Cardiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Background: Atherosclerotic process is considered to be the product of several influences, and there is no selective agent responsible for it. Around 50% of coronary heart disease (CHD) cases lack traditional risk factors such as hypertension, diabetes mellitus, smoking, dyslipidemia, and obesity in Indian subcontinent. Hence, nontraditional risk factors are increasingly used to determine patients at risk. The Aim of the Study: The study aimed to assess the nontraditional risk factors such as lipoprotein(a) (Lp[a]) and high-sensitivity C-reactive protein (Hs-CRP) as potential biomarkers in CHD patients and to correlate these factors with disease severity. Materials and Methods: This cross-sectional study was undertaken in 50 CHD patients and 50 healthy controls. Lp(a) and Hs-CRP along with other biochemical parameters were assessed in these patients. Results and Conclusion: Hypertriglyceridemia and hypertension were present in 74% and 62% of cases, respectively. Fasting blood sugar, triglyceride, and high-density lipoproteins were significantly altered in cases in comparison to control. Lp(a) (50.85 ± 23.42 mg/dl vs. 17.10 ± 5.18 mg/dl) and Hs-CRP (2.932 ± 0.605 vs. 0.379 ± 0.202 mg/dl) levels were raised significantly in cases when compared with the control (P < 0.001). A significant positive correlation was observed between Lp(a) and Hs-CRP. Hence, in addition to conventional parameters, the estimation of Lp(a) and Hs-CRP can prove to be a valuable tool in risk assessment of population and management of the disease.
Keywords: Atherosclerosis, coronary heart disease, high-sensitivity C-reactive protein, lipoprotein(a).