Lubna Khan1, Viquar Fatima Qureshi1, Tahira Jabeen1, Shoeb Qureshi2
1Department of Obstetrics and Gynecology, National Guard Health Affairs, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia.
2Department of Research, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Recurrent embryo implantation failure is a disorder with potentially dreadful physiological and psychological manifestations for those who are affected. Embryo implantation and formation of a functional placenta are processes that require a plethora of regulatory mechanisms involving both maternal and embryonic cells. In the ensuing overview, an attempt is made to understand (1) the pathophysiology of recurrent unexplained implantation failure (2) the available evidence for the two popular treatment modalities, i.e., intravenous immune globulin and intralipid, (3) the limitation of current available data, (4) the pathophysiology and immunomodulatory treatment options for recurrent implantation failure to address the pathological, psychological, and financial distress, and associated impact on couple’s quality of life.
Keywords: Intralipid, intravenous immune globulin, natural killer cells, recurrent implantation failure, reproductive immunology