Md. Badruzzaman1, Md. Zubbair Malik1, Md. Jahoor Alam2, G Reenaroy Devi2, Ravins2, RK Brojen Singh2, Shahnawaz ali1, Fauzul Mobeen3, Faez Iqbal Khan1
1Department of Computer Science, Jamia Millia Islamia, New Delhi-110025, India.
2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi – 110025, India.
3School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India


We study stochastic model of drug (Methylprednisolone) diffusion in rat hepatocytes and the impact of diffused drug in the cellular processes. The simple model involves various protein-protein interaction and protein-drug interaction pathways. We used stochastic simulation algorithm due to Gillespie in order to simulate the temporal dynamics of various proteins and drugs involved in these interaction. We found that the dynamics of mRNA and receptor (R) to be saturated after sometime (~10-20 hours). We also found that the decrease in drug population systematically as a function of time. Further we studied how the dynamics of each protein changes as a function of system size (V) and found that the population of each protein increases as V increases. Noise is always involved with each protein and drug dynamics. Read more…

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