Bioinformatique Structurale CNRS URA 2185 Institut Pasteur 75724 Paris, France.
Modern medicine, especially surgery, would not have been possible without general anaesthetics. Although they have been in use for over 160 years, their mechanism of action is still poorly understood. This talk addresses attempts to elucidate the molecular mechanisms of general anaesthesia, with special emphasis of how bioinformatics methods complement experiments. After a brief introduction of the putative anatomical site of action, I shall describe the role of the membrane and the GABA type A receptor in general anaesthetic action, and conclude how future research could be conducted. Read More …