Tarig Karar1, Rashed Ahmed R Alniwaider1, Mohamed Abdel Fattah1, Waleed Al Tamimi2, Abdullah Alanazi3, Shoeb Qureshi4
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia.
2Department of Pathology and Laboratory Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia.
3Department of Emergency Medical Services, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia.
4Department of Research Methodology, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia.
Aim: We aimed to evaluate the levels of urine microalbumin, urine albumin creatinine ratio, plasma creatinine and glycosylated hemoglobin (HbA1c) among type 2 diabetic patients and assessed the correlation between microalbuminuria and plasma creatinine levels. Materials and Methods: A retrospective chart review study was conducted at Department of Clinical Chemistry, King Abdulaziz Medical City in Riyadh, Saudi Arabia, during August to December 2014. The study included 100 male and female patients diagnosed with type 2 diabetes mellitus (DM) and excluding patients with type 1 DM. Medical history and biochemical laboratory data were obtained from medical records and from biochemistry laboratory database. Results: Increase in mean level of plasma creatinine (138 μmol/L), urine microalbuminuria (240 mg/L), albumin creatinine ratio (82) and HbA1c (8.7%) was observed among type 2 DM patients. Moderate positive correlation was observed between microalbuminuria and urine albumin creatinine ratio (r = 0.509 P = 0.0006) and between urine albumin creatinine ratio and plasma creatinine (r = 0.553 P = 0.017). Conclusion : We concluded that type 2 DM patients who are at risk of developing renal impairment must be regularly monitored for microalbuminuria, urine albumin creatinine ratio, and HbA1c levels.
Keywords: Albumin creatinine ratio, diabetes mellitus type 2, microalbuminuria.