Ratan Chandra Mandal¹, Debasish Bhar², Anjan Das³, Sandip Roy Basunia², Sudeshna Bhar Kundu⁴, Chinmay Mahapatra^1
1Department of Gynaecology and Obstetrics, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
²Department of Anaesthesiology, Midnapore Medical College and Hospital, Kolkata, West Bengal, India.
³Department of Anaesthesiology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
⁴Department of Anaesthesiology, IPGMER, Kolkata, West Bengal, India.
DOI: 10.4103/0976-9668.175080

ABSTRACT

Background: Prevalence of subclinical hypothyroidism (SCH) in pregnancy varies widely in different parts of our country, but it has multiple adverse outcomes in both the mother and fetus. Objectives: This study was conducted to evaluate the prevalence of SCH in pregnant women during the first trimester and to identify the prevalence of thyroid autoimmunity in pregnant women. Materials and Methods: This cross-sectional study (March 2014 to February 2015) was conducted among the pregnant women attending antenatal clinic in their first trimester at a tertiary care center. Morning samples of study participants were analyzed for free thyroxin (FT4), thyroid stimulating hormone (TSH), and thyroid peroxidase antibody (TPO Ab). Data expressed as mean ΁ standard deviation and percentage (%) as applicable. Results: Of the 510 subjects, 168 had TSH value >2.5 μIU/ml (32.94%) with normal FT4 and they were diagnosed as SCH. TSH level >4.5 μIU/ml was estimated in 13.92% (71) of the subjects. TPO Ab was positive in 57 (33.93%) of subclinical hypothyroid and 5 (1.47%) of normal subjects. 70.42% (50) of the subjects with TSH >4.5 μIU/ml had positive TPO Ab. Conclusions: Prevalence of SCH is high in South Bengal and routine thyroid screening at the first antenatal visit should be done to reduce the social and financial burden caused by SCH.

Keywords: Autoimmunity, first trimester, pregnancy, subclinical hypothyroidism.