The emerging assembly line of genomes to hit molecules In silico

The emerging assembly line of genomes to hit molecules In silico

May 26, 2012

B JayaramDepartment of Chemistry & Kusuma School of Biological Sciences & Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016, India. ABSTRACT Recent advances in genome sequencing projects and the concurrent developments in scientific softwares…

Predicting bio-molecular interactions in proteins and nucleic acids

Predicting bio-molecular interactions in proteins and nucleic acids

May 26, 2012

Shandar AhmadNational Institute of Biomedical Innovation, 7-6-8 Asagi-Saito, Ibaraki-City, Osaka, 567-0085, Japan. ABSTRACT All biological functions can ultimately be described in terms of interactions between proteins, nucleic acids and other smaller molecules. Molecular interactions provide for the enormous complexity of events in…

Exploring the protein complex forming ability in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks

Exploring the protein complex forming ability in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks

May 26, 2012

Tapash Chandra Ghosh, Sandip Chakraborty, Bratati KahaliBioinformatics Centre, Bose Institute, P 1/12, C.I.T. Scheme VII M, Kolkata 700 054, India. ABSTRACT Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level as illustrated…

Multi-domain protein kinases: Evolution of domain architectures, classification, hybrid protein kinases

Multi-domain protein kinases: Evolution of domain architectures, classification, hybrid protein kinases

May 26, 2012

N SrinivasanMolecular Biophysics Unit, Indian Institute of Science, Bangalore, India. ABSTRACT Protein phosphorylation is a generic way to regulate signal transduction pathways in all kingdoms of life. In many organisms, it is achieved by the large family of Ser/Thr/Tyr protein kinases which…

Structure-based drug design: Philosophy, strategy and some case studies

Structure-based drug design: Philosophy, strategy and some case studies

May 26, 2012

C Gopi MohanAmrita Centre for Nanosciences and Molecular Medicine (ACNMM), Amrita Institute of Medical Sciences, Ponekkara, Kochi- 682 041, Kerala State, India. ABSTRACT The process of going from a known structure of a pharmaceutical target to an active compound may seem both…

In silico analysis of enzymes associated with novel post-translational modifications of proteins and peptides

In silico analysis of enzymes associated with novel post-translational modifications of proteins and peptides

May 26, 2012

Shradha Khatar, Debasisa MohantyBioinformatics Center, National Institute of Immunology, New Delhi, India. ABSTRACT Post Translational Modification (PTM) typically involve covalent attachment of chemical groups to amino acids of a protein and they play a central role in intracellular signaling in both eukaryotic…

Prediction of the effects of missence mutations in human proteins

Prediction of the effects of missence mutations in human proteins

May 26, 2012

HA NagarajaramLaboratory of Computational Biology, Centre for DNA Fingerprinting & Diagnostics (CDFD), Gruhakalpa, Nampally, Hyderabad 500 00, Andhra Pradesh, India. ABSTRACT Phenotypic effects (“disease” and “neutral”) of a large number of missence mutations caused by nsSNPs as well as rare mutations have…

Genomics and proteomics pyro-sequencing based metagenomics of paddy soils from Uttar Pradesh, India

Genomics and proteomics pyro-sequencing based metagenomics of paddy soils from Uttar Pradesh, India

May 26, 2012

Sushmitha Vijaya Kumar, V Siva Karthik, Pa Ragul, R Aarthi, Vaibhav Bhatt, Prakash Koringa, Trupthi N PatelAnand Agricultural University, Anand, Gujrat, India. ABSTRACT Soil biota, the rhizosphere swarms with life in the form of microbes. India is one of the major paddy…

SNPs in cancer: A genome-wide computational analysis

SNPs in cancer: A genome-wide computational analysis

May 26, 2012

Ankita Mehta, Yasha HasijaDepartment of Biotechnology, Delhi Technological University (Formerly Delhi College of Engineering), Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India. ABSTRACT Cancer has been one of the common causes of morbidity and mortality worldwide. Also, geographic localization of cancers affecting certain…

Fungal diversity analysis of alkaline lake by next-generation sequencing technology

Fungal diversity analysis of alkaline lake by next-generation sequencing technology

May 26, 2012

Pravin R Dudhagara1, Anjana D Ghelani2, Shreyash A Bhatt31Department of lifesciences, Hemchandracharya North Gujarat University, Patan; Department of Biotechnology,VeerNarmad South Gujarat University, Surat, Gujarat, India.2Department of lifesciences, Hemchandracharya North Gujarat University, Patan; Shree Ramkrishna Institute of Computer Education and applied sciences, Surat,…