Nikolaos S Salemis1, Charalambos Seretis1, Fotios Seretis1, Charalambos Christofyllakis2, Georgios Karalis1
1 Department of Surgery, Army General Hospital, Athens, Greece Europe
2 Department of Medical Oncology, Army General Hospital, Athens, Greece, Europe

DOI: 10.4103/0976-9668.127325


Multifocal soft tissue sarcoma is a rare clinical entity occurring in 1% of patients with extremity soft tissue sarcoma and in 4.5% of patients with liposarcoma. Multifocal disease may arise either synchronously or metachronously and has been associated with poor prognosis. Herein, we have described a rare case of metachronous multifocal myxoid liposarcoma involving the gastrointestinal tract that developed 14 months after the resection of a myxoid buttock liposarcoma. Diagnostic evaluation and management of the patient are discussed along with a review of the relevant literature. We conclude that multifocal myxoid liposarcoma is a rare clinical entity that usually represents metastatic disease with poor prognosis. A thorough imaging and careful physical examination are essential in the preoperative evaluation and postoperative follow-up of patients with myxoid extremity liposarcomas, as these tumors are known to have a tendency to spread toward extrapulmonary sites, frequently without pulmonary metastases.

Keywords: Gastrointestinal, myxoid liposarcoma, multifocal, metachronous

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