In silico characterization of PFCYC-1, A cyclin homologue of Plasmodium falciparum

In silico characterization of PFCYC-1, A cyclin homologue of Plasmodium falciparum

May 26, 2012

Dinesh GuptaInternational centre for genetic engineering and biotechnology, Aruna Asaf Marg, New Delhi, India. ABSTRACT Malaria is still one of the deadly disease resulting in the death of million of people worldwide and situation has become worse due to antimalarial drug resistance….

A survey on recent developments in comparison of protein structure methods

A survey on recent developments in comparison of protein structure methods

May 26, 2012

KM Prakash Lingam1, S Chandrakala21Anna University of Technology, Chennai, India.2Dept. of Computer Science, Velammal Engineering College, Chennai, India. ABSTRACT Comparison of protein structures is an important tool for understanding the evolutionary relationships between proteins, predicting protein structures and thereby possibly predicting protein…

In silico structural analysis of a Brassica juncea sequence containing kinase specific domain

In silico structural analysis of a Brassica juncea sequence containing kinase specific domain

May 26, 2012

Javed Ahmad1, Mirza Sarwar Baig1, Irfan Qureshi1, Gohar Taj21Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.2Department of Molecular Biology and Genetic Engineering, G.B. Pant University of Agriculture & Technology, Pantnagar, India. ABSTRACT Protein kinase is a enzyme that modifies other proteins…

Prediction and classification of critical residues into fold and function using an information theoretic method

Prediction and classification of critical residues into fold and function using an information theoretic method

May 26, 2012

Mohd Rehan, Andrew M LynnJawaharlal Nehru University, New Delhi, India. ABSTRACT The residue conservation in a multiple alignment of a protein and its homologues indicates the importance of the residue for maintaining the structure and function of the protein. Often, the mutational…

Isozyme specific changes in antithrombin structure forms the basis of its improved heparin binding for anticoagulant activity

Isozyme specific changes in antithrombin structure forms the basis of its improved heparin binding for anticoagulant activity

May 26, 2012

Poonam Singh, Khushboo Singh, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT Antithrombin III (ATIII) is the main inhibitor of the coagulation proteases like factor Xa and thrombin. Anticoagulant activity of ATIII is…

Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

May 26, 2012

Qudsia Rashid, Md. Asim Azhar, Asma Naseem, Md. Sazzad Khan, Poonam Singh, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT An elevated prothrombotic state is a major risk factor for venous thromboembolism, atrial…

Role of helix B in serpin inhibition mechanism and polymerization

Role of helix B in serpin inhibition mechanism and polymerization

May 26, 2012

Poonam Singh, Monika Batra, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT Serine protease inhibitors (Serpins) are prone to conformation defects, however little is known about the factors and mechanisms which promote its…

Glycerol-3 phosphate acyltransferase structural and active site identification through In silico approach

Glycerol-3 phosphate acyltransferase structural and active site identification through In silico approach

May 26, 2012

Namrata Misra, Prasanna Kumar Panda, Lala Bihari SuklaBioresources Engineering Department, Institute of Minerals and Materials Technology (formerly Regional Research lab), Council of Scientific and Industrial Research, Bhubaneswar-751 013, Orissa, India. ABSTRACT Glycerol-3 phosphate acyltransferase (GPAT) is an enzyme in the triacylglycerol (TAG)…

Structure, function, and diversity of human carbonic anhydrase isozymes

Structure, function, and diversity of human carbonic anhydrase isozymes

May 26, 2012

Bushra Zubair1, Danish Idrees2, Faizan Ahmad2, Md. Imtaiyaz Hassan21NICT, Sikkim Manipal university, India.2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Carbonic anhydrase (CA) is a Zn +2 -containing enzyme that catalyzes the reversible…

In silico structural and functional analysis of the P74 protein related to the (PDV) Polyhedra Derived Virus infection of BmNPV into the silkworm

In silico structural and functional analysis of the P74 protein related to the (PDV) Polyhedra Derived Virus infection of BmNPV into the silkworm

May 26, 2012

HM Kantharaj, SK Ashwath, S.M.H QadriBioinformatics Centre, Central Sericultural Research and Training Institute, Mysore, India. ABSTRACT The proteomic studies in general and prediction and structural elucidation of protein, in particular adapt an in silico approach. With the advent of functional genomics and…