Protein-protein docking of serine proteinase of nematodes with plant proteinase inhibitors

Protein-protein docking of serine proteinase of nematodes with plant proteinase inhibitors

May 26, 2012

C.V.S. Siva Prasad, Saurabh Gupta, MD TiwariDepartment of Bioinformatics, Applied Science Division & IRCB, Indian Institute of Information Technology, Allahabad-21012, India. ABSTRACT Root-knot nematodes are plant-parasitic nematodes on horticultural and agricultural crops; they cause damage on root of the plant. Generally the…

Designing new leads for neuraminidase using Ab-initio approach

Designing new leads for neuraminidase using Ab-initio approach

May 26, 2012

Alka Shrivastava1, Mohd Nazir1, Chitra Gupta21Department of Computer Sciences, Jamia Millia Islamia University, Jamia Nagar, New Delhi-25, India.2Mascon Global Limited, 849, Udyog Vihar, Phase-V, Gurgaon, Haryana – 122016, India. ABSTRACT Influenza constitutes one of the most important upper respiratory tract infections regarding…

Molecular interaction studies of toxic proteins and neurotransmitters towards development of novel drugs for alzheimer disease

Molecular interaction studies of toxic proteins and neurotransmitters towards development of novel drugs for alzheimer disease

May 26, 2012

R Sathish Kumar, Murugesh Easwaran, C Nilavamudhan, P ShanmughavelDBT-Bioinformatics Center, Computational Biology lab, Bioinformatics Department, Bharathiar University, Coimbatore – 641046, Tamilnadu, India. ABSTRACT Amyloid beta, Presenilin, Apolipoprotein E and Acetylcholine structure−stability findings, emerges as an optimal target for alzheimer disease. The development…

In-silico inhibitor designing for HIV-1 integrase in Human Immunodeficiency Virus

In-silico inhibitor designing for HIV-1 integrase in Human Immunodeficiency Virus

May 26, 2012

Irin Sarah Jacob, Archana Singh, Sarika N Suryawanshi, Vikas GautamDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER) EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Acquired immune deficiency syndrome (AIDS) is a disease of the human immune…

In-Silico inhibitor designing for Plasmodiumfalciparum aspartate aminotransferase (Pfaspat) in malaria

In-Silico inhibitor designing for Plasmodiumfalciparum aspartate aminotransferase (Pfaspat) in malaria

May 26, 2012

Archana Singh, Irin Sarah Jacob, Vikas Gautam, Sarika N SuryawanshiDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Malaria remains one of the most prevalent infectious parasitic diseases worldwide killing…

In-Silico Modeling and Inhibitor Designing through Fragment Based Drug Discovery (FBDD) Approach for Arylamine N-Acetyltransferase (NAT) in Mycobacterium tuberculosi

In-Silico Modeling and Inhibitor Designing through Fragment Based Drug Discovery (FBDD) Approach for Arylamine N-Acetyltransferase (NAT) in Mycobacterium tuberculosi

May 26, 2012

Vikas Gautam, Archana Singh, Irin Sarah Jacob, Sarika N SuryawanshiDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER) EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Tuberculosis is one of the most prevalent infections of human beings and…

Carbohydrate ligand interactions with genotype variants of cholera toxin B

Carbohydrate ligand interactions with genotype variants of cholera toxin B

May 26, 2012

Sunil KumarInstitute of Life Sciences, Department of Biotechnology, Nalco Square, Bhubaneswar, India. ABSTRACT Vibrio cholerae produces cholera toxin (CT) that consists of two subunits, A and B, and is encoded by a filamentous phage CTXΦ. The A subunit carries enzymatic activity that ribosylates…

Receptor chemoprint based pharmacophore modeling and virtual screening approach to obtain the novel hits in search of dopamine receptor subtype selective and potent agonists

Receptor chemoprint based pharmacophore modeling and virtual screening approach to obtain the novel hits in search of dopamine receptor subtype selective and potent agonists

May 26, 2012

Amresh Prakash, Pranjul Mishra, Pratibha Mehta LuthraMedicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110007, India. ABSTRACT The ligand-based method has been very popular for a long time, however, the quality of…

Virtual screening studies for identification of novel antimalarials

Virtual screening studies for identification of novel antimalarials

May 26, 2012

Rahul Agarwal, Swarnima Kumari, Vikrant Nain, Shakti SahiSchool of Biotechnology, Gautam Buddha University, Greater Noida-201310, India. ABSTRACT Malaria remains a widespread and devastating disease. The CDC estimates that there are 300-500 million cases of malaria each year and more than 1 million…

Designing of a potent analog against drug resistant HIV-1 protease: An insilco study

Designing of a potent analog against drug resistant HIV-1 protease: An insilco study

May 26, 2012

Madhur Mishra, Mohammed Haris SiddiquiDepartment of Biotechnology, Microbiology and Bioinformatics, Integral University, Lucknow- 226026, India. ABSTRACT The HIV-1 protease enzyme is conscientious for the post translational processing of the viral Gag and Gag-Pol polyproteins to yield the structural proteins. The necessity of…