Acetoxy (4-aminophenyl) mercury, a chemical inhibitor for tankyrase 1 to control cell proliferation in cancer

Acetoxy (4-aminophenyl) mercury, a chemical inhibitor for tankyrase 1 to control cell proliferation in cancer

May 26, 2012

Anita Dubey, Tanmay Sahu, Suchi SmitaThe Bioinformatica Solutions, Lucknow (U.P), India. ABSTRACT Telomeres are repeated TTAGGG sequences that stop chromosome ends from behaving as random breaks. The up regulation of tankyrase1 protein encoded by TANKS gene (at Chromosome 8, NC_000008.10 (9413445..9639856)) in Homo…

Elimination of antibiotic resistance of NDM klebsiella pneumonia by inhibiting metallo beta lactamase 1 enzyme using combinational therapy of phytochemicals & antibiotics – An Insilico approach

Elimination of antibiotic resistance of NDM klebsiella pneumonia by inhibiting metallo beta lactamase 1 enzyme using combinational therapy of phytochemicals & antibiotics – An Insilico approach

May 26, 2012

Biplab Bhattacharjee1, Priya Prakash1, Rukmini Jonnalagadda1, BM Arpitha1, Jhinuk Chatterjee1, V Krishna Murthy1, Jayadev Joshi21Department of Biotechnology, PES Institute of Technology, Bangalore, India.2Radiation Biosciences Group, Institute of Nuclear Medicine & Allied Sciences (INMAS) – DRDO, New Delhi, India. ABSTRACT New Delhi metallo…

Computer aided screening of natural antimicrobials against putative drug targets of Helicobacter pylori 26695- an In silico drug designing approach

Computer aided screening of natural antimicrobials against putative drug targets of Helicobacter pylori 26695- an In silico drug designing approach

May 26, 2012

Biplab Bhattacharjee1, Jhinuk Chatterjee1, Priya Jacob2, V Krishna Murthy11Department of Biotechnology, PES Institute of Technology, Bangalore, India.2RV College of Engineering, Bangalore, India. ABSTRACT NHelicobacter Pylori is a bacterium that causes a chronic low-level inflammation of the stomach lining and is strongly linked to…

Designing and development of novel antituberculosis drugs by in silico targeting against Decaprenyl-phosphoryl-β-D-ribose oxidase: A structure based drug designing approach

Designing and development of novel antituberculosis drugs by in silico targeting against Decaprenyl-phosphoryl-β-D-ribose oxidase: A structure based drug designing approach

Richa AnandDepartment of Biochemical Engineering, Banaras Hindu university, UP, India. ABSTRACT Mycobacterium tuberculosis a causative agent of tuberculosis is gram-positive and slow growing bacterium. Decaprenyl-phosphoryl-β-D-ribose oxidase is an important enzyme involved in the cell wall synthesis of Mycobacterium tuberculosis. It is involved in…

In Silico structure based drug designing for schizophrenia

In Silico structure based drug designing for schizophrenia

May 26, 2012

Manika SehgalJUIT, Waknaghat, Solan, H.P., Shimla, India. ABSTRACT The current paper aims to design an in silico structure-based drug for treating the disease Schizophrenia. The word Schizophrenia (“split mind”) was coined by Eugen Bleuler in 1908.The disease manifests as abnormal thought processes, behaviour and…

Molecular modeling of the dimensional structure of EF-1α from Leishmania donovani and its interaction with several inhibitors

Molecular modeling of the dimensional structure of EF-1α from Leishmania donovani and its interaction with several inhibitors

Mukta Rani, Manas Ranjan Dikhit, Ganesh Chandra Sahoo, Pradeep DasBiomedical Informatics Division, Rajendra Memorial Research Institute of Medical Sciences, Agam Kuan, Patna 800007, India. ABSTRACT Visceral Leishmaniasis or Kala-azar is a protozoal parasitic devastating disease which takes a death toll of thousand of…

Model structure of ferroportin and its docking with hepcidin reveals structural basis of iron homeostasis

Model structure of ferroportin and its docking with hepcidin reveals structural basis of iron homeostasis

May 26, 2012

Prasoon Kumar Thakur1, Vishrant Tyagi2, Faizan Ahmad2, Md. Imtaiyaz Hassan21Department of Computer Science, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Hepcidin is a 25…

Comparative molecular docking approach on the series of antibacterial natural compounds for inhibition of NDM-1

Comparative molecular docking approach on the series of antibacterial natural compounds for inhibition of NDM-1

May 26, 2012

Prasoon Thakur1, Jitendra Kumar2, Divya Ray3, Md. Imtaiyaz Hassan41Department of computer science, Jamia Millia Islamia, New Delhi, India.2Beant College of Engineering &Technology, Gurdaspur, Punjab 143521, India.3Department of biotechnology, Post graduate government college, Chandigarh, Punjab, India.4Centre for Interdisciplinary Research in Basic Sciences, Jamia…